Do dampening effect on the central nervous system of ethanol, sedative and antipsychotic drugs (neuroleptics), antidepressants, narcotic analgesics, drugs for general anesthesia, muscle relaxants.
Inhibitors halotestin tablets of microsomal liver enzymes (including cimetidine, oral contraceptives, erythromycin, disulfiram, fluoxetine, isoniazid, ketoconazole, metoprolol, propranolol, propoxyphene, valproic acid) extend the T 1/2 and enhance the effect.
Inductors of microsomal liver enzymes (rifampicin, carbamazepine, caffeine) reduce efficiency.
Narcotic analgesics increase the euphoria, leading to an increase in psychological dependence.
Antacids drugs reduce the rate of absorption of diazepam from the gastrointestinal tract, but not its fullness.
Antihypertensive drugs may increase the severity of blood pressure reduction.
On the background of the simultaneous use of clozapine may increase the respiratory depression.
while the use of low polarity cardiac glycosides (digitoxin) may increase the concentration . the latter in blood serum and the development of glycoside intoxication (as a result of competition for the connection with halotestin tablets plasma proteins)
reduces the effectiveness of levodopa in patients with Parkinson’s disease.
omeprazole prolongs the elimination of diazepam.
monoamine oxidase inhibitors, analeptics, psychostimulants – reduce activity.
Premedication with diazepam reduces the dose of fentanyl required for introduction of general anesthesia and to reduce the time required to “off” consciousness via induction doses.
it may increase the toxicity of zidovudine.
Rifampin may increase excretion of diazepam and lowering its concentration in plasma.
Theophylline (used in low doses) may reduce or distort sedative act.
The risk of formation of drug dependence increases at high doses (60 mg / day), a significant duration of treatment, patients previously abusing alcohol or drugs. Without specific instructions, should not be used for a long time.
Not recommended for monotherapy of benzodiazepines with a combination of anxiety with depression (suicide attempts are possible). If you have any patients paradoxical reactions such as increased aggression, acute state of excitement, anxiety, anxiety, suicidal thoughts, hallucinations, increased muscle cramps, difficult to fall asleep, sleep surface, diazepam should be discontinued. Be wary appoint patients with personality and behavioral disorders. Paradoxical reactions are more common in children and elderly patients.
Acute glaucoma attack is a contraindication to the appointment of diazepam.
Diazepam can cause amnesia. The duration of amnesia depends on the dosage.
In the treatment of patients is strictly prohibited the use of ethanol. Smoking weakens the effect of the drug.
In renal / hepatic failure and prolonged treatment is necessary to monitor patterns of peripheral blood and the activity of “liver” enzymes.
It is not permissible abrupt discontinuation of treatment because of the risk of the syndrome of “cancellation” (convulsions, tremor, abdominal cramps and muscle pain, vomiting, sweating), but thanks to slow thehalotestin tablets diazepam expressed its manifestation is much weaker than that of other benzodiazepines.
Initiation of treatment with diazepam or abrupt withdrawal in patients with epilepsy or with a history of seizures may accelerate the development of seizures or status epilepticus.
When using large doses of diazepam developed mild hypotension. Patients with profound disorders of cardiac activity can develop significant hypotension, especially against the background of severe hypovolemia.
Children, especially at a younger age, are very sensitive to depress the central nervous system action of benzodiazepines.
In the period of treatment must be careful when driving vehicles and occupation of other potentially hazardous activities that require high concentration and speed of psychomotor reactions.