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Ftorhnnolon, the antimicrobial is a broad spectrum bactericidal action. Blocks  gyrase (topoisomerase II) and topoisomerase IV, and crosslinking gives supercoiling  breaks, inhibits  synthesis, causes profound morphological change in the cytoplasm, the cell wall and membranes of microorganisms.

Levofloxacin is active against most strains of microorganisms in conditions in vitro and in vivo.

In vitro:
Sensitive organisms (minimum inhibitory concentrationhalotestin buy.

Aerobic gram-positive microorganisms: Corynebactcrium diphtheriae; Enterococcus spp, incl Enterococcus faecalis…; Listeria monocytogenes; Staphylococcus spp. (.. Incl coagulase metitsillinchuvstvitslnye / moderately susceptible), Staphylococcus aureus (metitsillinchuvstvitelnye), Staphylococcus cpidermidis (metitsillinchuvstvitelnye); Streptococci of groups C and G, Streptococcus agalacliae, Streptococcus pneumoniae (penitsillinchuvstvitelnye / moderately sensitive / resistant), Streptococcus pyogenes, Streptococci Group Viridans.

Anaerobic microorganisms; Bacteroidcs fragilis; Bifidobacterium spp, Clostridium perfringens.; Fusobacterium spp .; Peptostreptococcus spp .; Propionibactcrum spp .; Veilonella spp.

Other micro-organisms: Bartonella spp .; Chlamydia pneumoniae, Chlamydia psillaci, Chlamydia trachomatis; … Legionella spp, incl Legionella pneumophila;Mycobacterium spp .. incl Mycobacterium leprae, Mycobacterium tuberculosis..; Mycoplasma hominis, Mycoplasma pneumoniae; Rickettsia spp., Ureaplasma urealylicum.

Levofloksatsin moderately active (MIC ≥4 mg / l):
Aerobic Gram-positive microorganisms: Corynebacterium urcalilicum, Corynebacterium xerosis; Entcrococcus faecium; Staphylococcus epidermidis (methicillin-resistant); Staphylococcus haemolyticus (methicillin-resistant).

Aerobic gram-negative halotestin buy microorganisms: Burkbolderia cepacia; Campilobacter jejuni. Campilobacter coli.

Anaerobic microorganisms: Bacteroides thelaiotaomicron, Bacteroides vulgatus, Bacteroides ovatus; Prevolella spp .; Porphyromonas spp.

By levofoloksatsinu resistant (MP K ≥ 8 mg / L):
Aerobic gram-positive mikpoopganizmy: Corynebacterium jeikeium; Staphylococcus aureus (methicillin-resistant), Staphylococcus spp. . koagulazonsgativnye (methicillin-resistant)
Aerobic gram-negative microorganisms:. Alcaligenes xylosoxidans
Other micro-organisms: Mycobacterium avium.

With intravenous administration of single and multiple apparent volume of distribution after administration of the same dose of 89-112 l.

Relationship to plasma proteins – 30-40%. Well into the organs and tissues – lungs, bronchial mucosa, sputum, organs of the urogenital system, bone tissue, cerebrospinal fluid, the prostate gland, polymorphonuclear leukocytes, alveolar macrophages.

Metabolism and excretion: In the liver, a small part of the oxidized and / or deacetylated. Report from the body mainly by the kidneys by glomerular filtration and tubular secretion. The half-life – 6.4 hours.

In renal insufficiency, reduced clearance of the drug and its excretion by the kidneys is dependent on the degree of decline in creatinine clearance.

Indications
Infectious-inflammatory halotestin buy diseases, caused by susceptible microorganisms:
– lower respiratory tract (exacerbation of chronic bronchitis, community-acquired pneumonia);
– LOP-organs (including acute sinusitis);
– by mochevyyvodyaschih and kidney (including acute pyelonephritis);
– bacterial chronic prostatitis;
– skin and soft tissue infections (atheroma festering abscess, furunculosis);
– septicemia / bacteremia;
– intra-abdominal infections;
– in the complex therapy of drug-resistant forms of tuberculosis.

Contraindications
– giperchuvstvitslnost (including to other quinolones);
– epilepsy;
– the defeat tendons at the earlier treatment of quinolones;
– childhood and adolescence (growth period) 18;
– Pregnancy
– Lactation;

With care : the elderly (due to the high probability of the presence of a concomitant decrease in renal function), with a deficit of glucose-6-fosfatdsgidrogenazy. anabolic steroids online shop

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