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Benign and malignant liver tumors (adenomas and hepatocellular carcinoma) are rare. Studies such as “case-control” showed that the risk of these tumors can be increased by using oral contraceptives and depends on the duration of their use. Rupture of benign liver adenomas may cause death due to internal buy halotestin bleeding.

Cancer genital and breast
cancer incidence of breast, endometrial, ovarian and cervical cancer in women who use oral contraceptives have been the subject of study of numerous epidemiological studies. There are conflicting results, but the data of the majority of studies have shown that the use of oral contraceptives is not associated with an overall increase in the risk of breast cancer. Some authors have reported an increased relative risk of breast cancer, especially in young women. It has been shown that the increased relative risk depends on the duration of use of oral contraceptives.
A meta-analysis of buy halotestinepidemiological studies has shown that women who use combined oral contraceptives are currently, or have taken them in the preceding 10 years, slightly increased risk of breast cancer detection . On the basis of these data, it is impossible to determine whether the increased risk is due to an earlier diagnosis of breast cancer in women who had ever used oral contraceptives, the biological effects of hormonal contraceptives, or a combination of these two factors. This meta-analysis also gives reason to believe that the age at which women stop taking combined oral contraceptives is an important risk factor for breast cancer: the older the age, the more frequently diagnosed with breast cancer. The duration of use of oral contraceptives does not play such an important role.
Before the appointment of female oral contraceptive it is necessary to discuss the possibility of an increased risk of breast cancer and to correlate this risk with the use of combined oral contraceptives.
Some epidemiological studies have shown that long-term use of oral contraceptives is accompanied by an increased risk of cervical tumors uterus. Coherence of the data with the reception of combined oral contraceptives has not been proved. It should be noted, however, the uncertainty of the extent to which these data may be due to differences in the sexual behavior and other factors.

Metabolic Effects
Oral contraceptives may buy halotestin decrease glucose tolerance. It was shown that this effect is directly related to the dose of estrogen. In addition, progestogens can enhance insulin secretion and induce insulin resistance, and this effect varies with different progestogens. However, it should be noted that in women without diabetes, oral contraceptives are most likely not affect the level of blood glucose. Given this, it is necessary to closely monitor the status of women with impaired glucose tolerance or diabetes taking oral contraceptives. A small percentage of women while taking oral contraceptives there is persistent hypertriglyceridemia. Women who use oral contraceptives have been observed changes in serum triglycerides and lipoprotein.

Headache
In the case of the emergence or strengthening of a migraine, as well as the emergence of a new type of headache that is recurrent, persistent or severe, you must stop taking oral contraceptive, and determine the cause of the headache.

Menstrual disorders
in women who use oral contraceptives, especially during the first 3 months of their reception may occur intermenstrual bleeding, spotting and / or amenorrhea. Consideration should be given hormonal reasons for such violations and, if necessary, to the appropriate diagnostic procedures to exclude cancer or pregnancy.
In some women, while taking oral contraceptives may occur amenorrhea or oligomenorrhea, especially if these conditions were observed prior to use contraceptive drug.

Chloasma
While taking oral contraceptives sometimes there chloasma, especially in women with a history of chloasma during pregnancy. Women who are prone to develop chloasma should avoid the sun and buy halotestin ra exposure during use of oral contraceptives. Chloasma is often not fully disappear. anabolic steroids net epic bodybuilding motivation dianabol blue hearts crazy bodybuilding motivation buy dianabol online la pharma controlled delivery steroids stoppani bodybuilding clomid 50 mg bodybuilding chest workout

fluoxymesterone-halotestin

fluoxymesterone

Oral contraceptives do not protect against HIV infection fluoxymesterone and other sexually transmitted diseases through.
Recommended to compile a complete medical history and conduct a thorough physical examination Before prescribing oral contraceptive patient. Surveys need to be repeated periodically, in accordance with the standards of quality obstetric care.
Before assigning the patient oral contraceptive she need to find out what herbal remedies it takes, as well as to review the information in the package insert for drugs that a woman will be taken with oral contraceptives.
In the presence of undiagnosed, persistent or recurring abnormal vaginal bleeding is necessary to exclude a malignant tumor.
after suffering a hepatitis oral contraceptive can be administered after 3 months (in severe cases after 6 months) after normalization of liver function test results.

Thromboembolic and other vascular complications
was found that the use of oral contraceptives increases the risk of thromboembolic complications, and thrombosis. Studies such as “case-control” showed that the relative risk in women using oral contraceptives compared with those who did not use these drugs, is 3: 1 for the first episode of thrombosis fluoxymesterone of superficial veins, 11: 4 for deep vein thrombosis or thromboembolism pulmonary artery and 6: 1,5 in women with diseases predisposing to thromboembolic complications. Studies have demonstrated that the relative risk is somewhat lower, about 3: 1 for new cases and about 4.5: 1 for the new cases requiring hospitalization. The risk of thromboembolic complications associated with the use of oral contraceptives, does not depend on the duration of taking these drugs and disappears after cessation of administration.
Women who use oral contraceptives, the relative risk of postoperative thromboembolic complications increased by 2-4 times. The relative risk of venous thrombosis in women with disease predisposing to this complication, a 2-fold higher than in women without such diseases. If possible, oral contraceptives should not be taken at least 4 weeks before and for two weeks after elective surgery is associated with increased risk of thromboembolism as well as during prolonged immobilization and recovery period. In the early post-natal risk of thromboembolic complications also increased, and so women who choose not to breastfeed may start taking oral contraceptives no earlier than 3 weeks after giving birth. After artificial or spontaneous abortion that took place on the 20th week of pregnancy or later, the use of hormonal contraceptives can be started either on Day 21 post-abortion or on the first day of the first spontaneous menstruation, whichever comes first.
The relative risk arterial thrombosis (eg stroke, myocardial infarction) is increased in the presence of other predisposing factors such as smoking, hypertension, hyperlipidemia, obesity, diabetes, a history of pre-eclampsia and elderly age. These severe vascular complications were observed in women who took oral contraceptives with estrogen content of 50 micrograms or more. The risk of vascular complications is less likely when using oral contraceptives containing less than high doses of estrogen and progestogen, but this assumption has not yet received solid proof.
The risk of serious cardiovascular fluoxymesterone side effects increases with age, as well as in heavy smokers. This risk is very high in smokers older than 35 years. Women using oral contraceptives should be strongly encouraged to stop smoking.
It has been reported on the increase in blood pressure in women taking oral contraceptives. Studies have shown that long-term use of estrogen in a dose of 50 micrograms or more, increasing the likelihood of blood pressure increases with age. Many women after discontinuation of oral contraceptives, blood pressure normalized. Unable to identify the differences in the frequency of hypertension in women, which in the past have taken oral contraceptives and in women who had never taken such drugs.
In women with hypertension (persistent blood pressure of 140-159 / 90-99 mm Hg. Art. ) before taking an oral contraceptive is necessary to normalize blood pressure. In the event of a major increase in use of oral contraceptives should be discontinued in blood pressure.
There have been reports of the occurrence of retinal thrombosis associated with the use of oral contraceptives. Use of oral contraceptives should be discontinued in the event of unexplained transient, partial or complete loss of vision; the appearance of the veil before the eyes, or double vision; nipple swelling of the optic nerve or the occurrence of retinal vascular changes. In such cases, an urgent need to implement fluoxymesterone appropriate diagnostic and therapeutic actions. buy anabolic steroids online bruce lee’s workout anabolic steroids online uk cuanto cuesta whey protein mejor marca de proteinas unflavoured whey protein

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halotestin side effects

Halotestin side effects should start with a single oral medication on the first day of menstrual bleeding. Thereafter, for 20 days is necessary to take one tablet daily. This is followed by a seven-day break from taking the drug. Usually, a few days after taking the pills comes menstrual-like bleeding.
The next cycle should begin receiving Silest on the eighth day, ie seven days after discontinuation of the tablets in the previous cycle. The first cycle of the new tablet should be taken regardless of whether stopped or is still ongoing bleeding. In a blister pack affixed preparation days of the week. For the convenience of checking the regularity of taking the pills is recommended to start a new cycle with a pill marked with the data of day of the week, and continue to continue without interruption the entire cycle of administration.
Contraceptive pills have the highest efficiency, if taken at one and the same time of day, for example, in the morning.
In case of skipping the usual time of receipt, the tablet should be taken immediately. Retreat from the ordinary reception time up to 12 hours provides a reliable contraceptive effect. Efficacy is reduced by the delay in taking the pill more than 12 hours. If the usual time of the drug more than 12 hours or missed reception of more than one tablet, the drug should be resumed immediately, leaving the package missed tablet. However, before the end of this cycle should use additional means of protection against pregnancy, such as condoms or vaginal contraceptive suppository. In such situations, you can not rely on the method of “safe days” or “temperature” method of contraception.
After the birth of halotestin side effects a child receiving Silest should be started no earlier than 4 weeks after delivery, provided that the woman is not breastfeeding.
After an abortion or miscarriage on term up to 20 weeks of pregnancy pill intake, you can start immediately, in these cases the use of additional contraception is needed. After an induced or spontaneous abortion on gestational age over 20 weeks of hormonal contraceptives can be used to start at day 21 post-abortion or on the first day of menstruation natural appearance (whichever comes first). In these cases, during the first 7 days of the cycle is recommended to use additional local contraceptives in addition to receiving Silest. In exceptional cases, if there is medical evidence to ensure immediate reliable contraception, Silest reception can be initiated 1 week after abortion. It should be borne in mind that the risk of thromboembolic complications increased with the admission to the post-abortion.
If you have vomiting or diarrhea Silest can lose its effectiveness, as it takes 4 hours for a full assimilation by the body of the tablet. In this case, it is recommended to continue receiving Silest, complementing its action other contraceptives before the onset of menstruation.

Side effects Cardiovascular system : hypertension, myocardial infarction, cerebrovascular accident, deep vein thrombosis, arterial thrombosis, pulmonary or other vessels, swelling. Tumors : benign and malignant liver tumors, cervical cancer and breast cancer. Hepatobiliary system : cholestatic jaundice, BaddaKiari syndrome, intrahepatic cholestasis, cholelithiasis. Gastrointestinal tract : nausea, vomiting, abdominal pain, flatulence, colitis. Genitals : intermenstrual bleeding, spotting, amenorrhea, changes in the menstrual cycle, increase in fibroid size of the uterus, vaginal candidiasis increase in cervical secretions, cervical erosion, decreased libido, PMS, temporary infertility after discontinuation of the drug breast cancer : pain and sense of tension, galactorrhea, engorgement, increase in size, a reduction of lactation at the reception immediately after birth. Skin : erythema nodosum, skin rash, chloasma, erythema, acne, seborrhea, alopecia, hirsutism, pigmentation spots on the face, hypertrichosis, pemphigoid (gestational herpes), melasma with a tendency to persistence. organ of vision : cataracts, lesions of the optic nerve, changes in corneal curvature, discomfort while wearing contact lenses. Central nervous system : headache, mood changes, irritability, depression, chorea. Metabolism : fluid retention, weight change (increase or decrease), reduced glucose tolerance, change in appetite. kidney : reduction of renal function, hemolytic -uremichesky syndrome. Other :. dizziness, migraine When menstrual-like bleeding, reception Silest should continue. If the bleeding does not stop, it is necessary to conduct a survey to exclude organic causes. These recommendations concern and spotting that can occur sporadically for several cycles or receiving Silest first time after a prolonged ingestion. If at the end of the cycle of the drug the bleeding does not occur, it is necessary to exclude pregnancy before starting a new cycle of receiving Silest.

 

Overdose
No serious cases halotestin side effects of poisoning due to overdose Silest not mentioned. In case of overdose can cause nausea, vomiting, and vaginal bleeding.
No specific antidote exists. In case of overdose should be gastric lavage (within the first hour after ingestion) and symptomatic therapy.

Interaction with other medicinal products and other forms of interaction
Drugs that cause the induction of enzymes that metabolize estrogens (eg, estrogen 2-hydroxylase – coenzyme 3A4 cytochrome P-450), reduce the contraceptive efficacy of hormonal drugs. It is also possible that the induction of these same isozymes may result in a reduction in blood concentration of the drug Silest progestogen component. Potentially clinically significant in this respect are the drugs and herbal drugs affecting enzymes which are involved in the biotransformation of contraceptive steroid (for example, St. John’s wort, barbiturates, carbamazepine, phenytoin, sulfonamides, pyrazolone derivatives, rifampicin).
It has been shown that some inhibitors protease and some antiretroviral drugs increase (for example, indinavir) or lower (e.g., ritonavir) halotestin side effects concentration in the blood combined hormonal contraceptives.
Another type of interaction is to tackle intrahepatic circulation estrogens, whereby elimination is accelerated and reduces the concentration of ethinyl estradiol. When co-administered with some antibiotics (such as ampicillin or tetracycline) was observed lack of estrogen conjugates cleavage of fatty acids by intestinal bacteria. how much to inject for weight loss

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halotestin-10mg-pro-chem

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When taken orally is well absorbed norgestimate either alone or in combination with ethynyl estradiol. The maximum concentration halotestin for sale in plasma is achieved in 1-2 hours. Norgestimate is extensively metabolised. The half-life is about 4 hours. The metabolites are excreted slowly. After 2 weeks, 50% of the active substance is excreted with urine and approximately 40% – in the feces. Ethinyl estradiol is rapidly and almost completely absorbed after oral administration.  Achieved within 1-2 hours in the blood plasma.

Ethinyl estradiol is only partially metabolized in the body. The half-life is 4.5 hours. More than 17% of the active substance is excreted unchanged in the urine and 10% is excreted in the feces. Metabolites are estradiol, estriol and mainly 2-16ß-hydroxy- and gidroksietinilestradiol.

Indications
Contraception in females

Contraindications

 

  • hypersensitivity to any component of the drug;
  • venous thrombosis, including a history (including deep vein thrombosis, pulmonary embolism);
  • hypersensitivity to any component of the drug;
  • venous thrombosis, including a history (including deep vein thrombosis, pulmonary embolism);
  • arterial thrombosis, including history (including acute cerebrovascular accident, myocardial infarction, thrombosis, retinal artery) or thrombosis precursors (including angina or transient ischemic attack);
  • presence of serious or multiple risk factors of arterial thrombosis:

– Arterial hypertension (persistent elevation of blood pressure above 160/100 mm Hg..);- Diabetes mellitus with vascular disease;- Hereditary dislipoproteinemia;

  • hereditary predisposition for venous or arterial thrombosis, such as antithrombin deficiency-III, protein C deficiency, protein deficiency of the S, hyperhomocysteinemia, the presence of antiphospholipid antibodies (anti-cardiolipin, a group of antibodies against negatively charged phospholipids);
  • migraine with aura;
  • confirmed or halotestin for sale suspected breast cancer;
  • cancer of the endometrium or other known or suspected estrogen-dependent tumors;
  • benign or malignant liver tumors;
  • genital bleeding of unknown etiology;
  • postmenopausal;
  • age of 18 years;
  • postpartum period (4 weeks.);
  • lactation;
  • confirmed or suspected pregnancy;
  • cholestatic jaundice during pregnancy, including and in history;
  • sickle cell anemia;
  • liver failure;
  • hemolytic anemia;
  • otosclerosis.

 

Carefully:

 

  • venous or arterial embolism in siblings or parents at a relatively young age;
  • prolonged immobilization, or extensive surgery;
  • Risk factors for coronary heart disease such as smoking, hyperlipidemia, hypertension or obesity;
  • hypertension (persistent blood pressure levels of 140-159 / 90-99 mm Hg..);
  • thrombophlebitis of superficial veins and varicose veins;
  • valvular lesions with complications (mitral stenosis with atrial fibrillation);
  • diabetes;
  • severe depression or the presence of the disease history;
  • systemic lupus erythematosus;
  • Crohn’s disease;
  • ulcerative colitis;
  • hypertriglyceridemia, including family history;
  • acute liver dysfunction during previous pregnancy or previous use of sex hormones;
  • menstrual irregularities;
  • renal dysfunction;
  • gallbladder disease;
  • epilepsy;
  • uterine fibroids;
  • breast;
  • tuberculosis.

 

The use of pregnancy and lactation
The drug is contraindicated in pregnant women Silest.
Epidemiological studies have found no increased risk of birth defects in children whose mothers before pregnancy, oral contraceptives. Most modern studies also found teratogenic effects, particularly heart anomalies and shortening of the limbs, the offspring of women who, during pregnancy, mistakenly took oral contraceptives.
Combined oral halotestin for sale contraceptives may interfere with lactation, ie, reduce the amount and change the composition of breast milk. In addition, a small portion of contraceptive steroids and / or their metabolites may penetrate into breast milk. Therefore Silest is contraindicated during breast-feeding.

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Halotestin 10

fluoxymesterone halotestin

It is not known whether this drug in human milk. Because many drugs are determined in human milk, should stop breast-feeding or stop taking the drug, taking into account the importance of the treatment to the mother.

special instructions

In connection fluoxymesterone halotestin with the suppression of bone marrow function, it should be analyzed weekly blood cells for at least six weeks after taking the prescribed dose.

Along with the study of pulmonary function in patients before starting treatment, repeated studies during treatment should be carried out. For high-risk group includes patients with the proper performance of forced vital capacity and lung diffusion capacity below 70%.

Since Shiina may impair liver function, you must periodically carry out appropriate analyzes. You should also periodically check kidney function.

Side effect

Digestive tract

After 3-6 hours after administration Shiina may experience nausea and vomiting that typically last up to 24 hours. The frequency and duration of these side effects can be reduced through the use of antiemetic drugs before taking Shiina, as well as through the appointment Shiina patients fasting.

Toxicity with respect to the hematopoietic system

The main fluoxymesterone halotestin and the most severe toxicity associated with late Shiina suppression of bone marrow function, which usually occurs within 4-6 weeks after drug administration and is dose-dependent.Thrombocytopenia develops an average of 4 weeks and may persist for 1-2 weeks. Approximately 6 weeks after receiving Shiina develop leukopenia, persistent for 1-2 weeks. Approximately 65% of patients with WBC counts may be less than 5000 / mm 3 and 36% of patients less than 3000 / mm 3 . Typically, thrombocytopenia is more severe than leukopenia. However, both types of toxicity may limit the dose.

Shiina may cause cumulative myelosuppression, and after receiving repeated doses may experience more pronounced bone marrow suppression or myelosuppression duration can be greater. It was reported on acute leukemia and bone marrow dysplasias as a result of treatment nitrosourea drugs.

There may also be anemia, but it develops less often and is less severe, than thrombocytopenia and leukopenia.

The toxic effects on the lungs

In rare cases it reported appearance of infiltrates in the lungs and / or lung fibrosis Shiina during use. The appearance of toxic effects observed after 6 months (or over longer periods) after the start of treatment with cumulative doses of the drug more than 1100 mg / m 2 . It reported one case of pulmonary toxicity at a cumulative dose of only 600 mg.

Other toxic effects

In rare cases, it noted the appearance of stomatitis, alopecia and anemia. A number of patients treated with Shiina, observed neurological reactions such as confusion, lethargy, ataxia, and speech articulation disorder. However, the relationship of these effects to the drug intake in these patients has not been established.

Nephrotoxicity

In patients receiving high cumulative doses of the drug in a long-term treatment Shiina and other drugs nitrosoureas, marked renal dysfunction, is a reduction of kidney size, progressive azotemia and renal failure. Occasionally also reported kidney damage in patients receiving lower total doses.

Toxic effects on the liver

It was reported a reversible toxic effect on the liver, manifested in the fluoxymesterone halotestin increase in transaminases, alkaline phosphatase and bilirubin, a small percentage of patients treated with Shiina.

 

Dosing and Administration

Shiina recommended dose in adults and children is 130 mg / m 2 after a single ingestion every 6 weeks.

In patients with reduced bone marrow function the dose can be reduced  , while maintaining a six-week interval between doses.

Repeated courses Shiina should not be used when the number of platelets less and the number of white blood cells less than 4000 / mm 3 , because the hematologic toxicity is late and is cumulative. The content of blood cells should be checked weekly.

 

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