Benign and malignant liver tumors (adenomas and hepatocellular carcinoma) are rare. Studies such as “case-control” showed that the risk of these tumors can be increased by using oral contraceptives and depends on the duration of their use. Rupture of benign liver adenomas may cause death due to internal buy halotestin bleeding.
Cancer genital and breast
cancer incidence of breast, endometrial, ovarian and cervical cancer in women who use oral contraceptives have been the subject of study of numerous epidemiological studies. There are conflicting results, but the data of the majority of studies have shown that the use of oral contraceptives is not associated with an overall increase in the risk of breast cancer. Some authors have reported an increased relative risk of breast cancer, especially in young women. It has been shown that the increased relative risk depends on the duration of use of oral contraceptives.
A meta-analysis of buy halotestinepidemiological studies has shown that women who use combined oral contraceptives are currently, or have taken them in the preceding 10 years, slightly increased risk of breast cancer detection . On the basis of these data, it is impossible to determine whether the increased risk is due to an earlier diagnosis of breast cancer in women who had ever used oral contraceptives, the biological effects of hormonal contraceptives, or a combination of these two factors. This meta-analysis also gives reason to believe that the age at which women stop taking combined oral contraceptives is an important risk factor for breast cancer: the older the age, the more frequently diagnosed with breast cancer. The duration of use of oral contraceptives does not play such an important role.
Before the appointment of female oral contraceptive it is necessary to discuss the possibility of an increased risk of breast cancer and to correlate this risk with the use of combined oral contraceptives.
Some epidemiological studies have shown that long-term use of oral contraceptives is accompanied by an increased risk of cervical tumors uterus. Coherence of the data with the reception of combined oral contraceptives has not been proved. It should be noted, however, the uncertainty of the extent to which these data may be due to differences in the sexual behavior and other factors.
Oral contraceptives may buy halotestin decrease glucose tolerance. It was shown that this effect is directly related to the dose of estrogen. In addition, progestogens can enhance insulin secretion and induce insulin resistance, and this effect varies with different progestogens. However, it should be noted that in women without diabetes, oral contraceptives are most likely not affect the level of blood glucose. Given this, it is necessary to closely monitor the status of women with impaired glucose tolerance or diabetes taking oral contraceptives. A small percentage of women while taking oral contraceptives there is persistent hypertriglyceridemia. Women who use oral contraceptives have been observed changes in serum triglycerides and lipoprotein.
In the case of the emergence or strengthening of a migraine, as well as the emergence of a new type of headache that is recurrent, persistent or severe, you must stop taking oral contraceptive, and determine the cause of the headache.
in women who use oral contraceptives, especially during the first 3 months of their reception may occur intermenstrual bleeding, spotting and / or amenorrhea. Consideration should be given hormonal reasons for such violations and, if necessary, to the appropriate diagnostic procedures to exclude cancer or pregnancy.
In some women, while taking oral contraceptives may occur amenorrhea or oligomenorrhea, especially if these conditions were observed prior to use contraceptive drug.
While taking oral contraceptives sometimes there chloasma, especially in women with a history of chloasma during pregnancy. Women who are prone to develop chloasma should avoid the sun and buy halotestin ra exposure during use of oral contraceptives. Chloasma is often not fully disappear.