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halotestin

It is believed that Shiina acts as an alkylating agent, however, and other nitrosoureas, Shiina may inhibit certain enzymatic reactions.

In studies with radiolabeled drug Shiina after oral doses of halotestin half of the radioactivity excreted in approximately 24 hours. The half-life of the parent drug and / or its metabolites of serum varies from 16 hours to 2 days. The concentration in the tissue close to the blood plasma concentration 15 minutes after intravenous administration.

Due to the high lipid solubility and almost complete lack of ionization at physiological pH, Shiina effectively penetrate the blood-brain barrier. concentration  or more with respect to the concentrations of which are determined simultaneously in the plasma.

 

Indications for use:

Shiina shown palliative therapy in addition to other forms of treatment, or in standard circuits combination therapy with other chemotherapeutic agents known under the following conditions:

Brain tumors: primary tumors and metastases in patients who have already received appropriate surgical and / or radiation treatment;

Lymphogranulomatosis: as a second-line treatment.

Other tumors: Shiina used in combination with other chemotherapeutic agents in cases only conventional applications of unsuccessful therapies.

WARNINGS

Shiina should be halotestin used under the supervision of physicians experienced with antineoplastic drugs.

The most severe manifestations of toxicity Shiina associated with thrombocytopenia and leukopenia, against which in debilitated patients may experience bleeding and severe infection.

It is a weekly analysis of blood cells for at least 6 weeks after receiving the prescribed . Shiina in the recommended doses should not be administered more frequently than six weeks.

Shiina toxicity against bone marrow is cumulative, so the dose adjustment should be based on the minimum content of blood cells values after administration of the last dose (see. Table correct dose in the “Dosage and administration”).

Care should be taken when appointing Shiina patients with low levels of platelets, white blood cells and red blood cells in the peripheral .

Pulmonary toxicity Shiina is dose dependent .

It has been reported about the possibility of the development of secondary malignancies with prolonged use of nitrosoureas.

Periodically check the function of the liver and kidneys halotestin.

Pregnancy

The safety of the drug during pregnancy has not been established. In animal studies revealed that Shiina teratogenic and embryotoxic at doses equivalent to those used in humans. If necessary, use of the drug in pregnant or if pregnancy occurs during treatment, patients should be warned about the potential risk to the fetus. Women of childbearing age should be advised to avoid becoming pregnant.

Carcinogenesis, Mutagenesis, Impairment of reproductive function

Animal studies have shown that Shiina has a carcinogenic effect, causing a marked increase in tumor incidence in doses approximating those applied in the clinic, as well as the impact on reproductive function at doses somewhat higher than those used in humans.

nitrosourea drugs have the potential carcinogenicity. It was reported on acute leukemia and bone marrow dysplasias as a result of treatment with nitrosourea. steroiden kaufen

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halotestin cycle

Has venodilatiruyuschee, antiplatelet, analgesic and anti-anginal action. Venodilatiruyuschaya activity after release due to a number of metabolic conversions of nitrogen oxide , stimulating soluble guanylate cyclase, thereby molsidamin considered “donator” . The accumulation of cGMP causes the relaxation of smooth muscle cells of the vascular wall (to a greater extent – the veins). Reduced preload, even without a direct effect on myocardial contractility, leading to the restoration of impaired in patients with coronary insufficiency ratio between the demand for oxygen and its intake (26% reduced oxygen demand). Can expand capable of vasodilation narrowed sections of coronary arteries, improves tolerability krovoobraschenie.Uvelichivaet collateral loads, reduces the number of angina attacks that occur during exercise. Suppresses the early phase of platelet aggregation, reduces isolation and synthesis of serotonin, thromboxane and other proagregantov. In patients with chronic heart failure, reducing preload, it helps to reduce halotestin results the size of the heart chambers. It reduces pressure in the pulmonary artery, reduces the filling of the left ventricle and myocardial wall stress, stroke volume. The action starts after 20 min after oral administration, reaching a peak after halotestin cycle hours and lasts up to six hours. In contrast to nitrate, development of tolerance with a decrease in effectiveness during prolonged therapy is unusual.

After oral administration almost completely absorbed from the gastrointestinal tract. Bioavailability – 60-70%. The maximum concentration is achieved (4.4 ug / ml) -1ch. When administered after food intake although slowing, but not reduced (maximum plasma concentration is reached 30-60 minutes later than in the fasting state). The minimum effective concentration of molsidomine in plasma of 3-5 ng / ml. Almost does not bind to plasma proteins. The liver is metabolized to pharmacologically active compound SIN-1 (3-morpholino-sydnonimine), which is formed from a very unstable substance SIN-la (N-morpholino-N-aminosintonitril) releasing to form pharmacologically inactive compounds SIN-lc. And other metabolites halo cycle are produced during the metabolism. Excreted by the kidneys by 90% (in the form of metabolites), 9% – via the intestine. Thehalotestin cycle accumulates (including in patients with renal insufficiency). In severe hepatic impairment (increased bromsulfaleinovoy samples up to 20-50%) observed slowing clearance and an increase in its concentration in blood plasma.

Contraindications: Hypersensitivity to the drug, severe hypotension (systolic blood pressure below 100 mm Hg), collapse, cardiogenic shock, low pressure filling of the left ventricle, acute myocardial infarction, flowing with arterial hypotension, toxic pulmonary edema, concomitant use of sildenafil, bsrsmsnnost, lactation, age 18 years (effectiveness and safety have been established).

Be wary of patients after suffering a hemorrhagic stroke, with increased intracranial pressure, patients prone to hypotension; older age, glaucoma (especially the closure), cerebrovascular accident.

Dosing and Administration Inside, regardless of meals. Tablets are swallowed whole, without chewing and drinking plenty of fluids. With the lack of expression of the therapeutic effect of the multiplicity of purposes increased to 3 times a day. The maximum daily dose of 6 mg. The dosage and duration halotestin cycle of treatment is determined individually.

Side effects Headache (usually slight, disappears in the course of further treatment); decrease in blood pressure, collapse (when the initially high blood pressure (BP), the severity of its decline is greater than the initially normal or reduced blood pressure); redness of the skin; slowing of mental and motor reactions (mainly at the beginning of the treatment); dizziness; nausea, loss of appetite, diarrhea; tachycardia; allergic reactions (skin rash, pruritus, bronchospasm, rarely – anaphylactic shock).

Overdose Symptoms: severe headaches, marked reduction of blood pressure, tachycardia. Treatment: symptomatic.

Interaction with other drugs severity of the hypotensive effect enhanced by the simultaneous administration with other vasodilators, antihypertensive drugs and ethanol. Aspirin increases the antiplatelet activity.

Cautions Do not use for halotestin cycle the relief of angina attacks! Be wary (and under the control of blood pressure) appoint the first dose, there may be intense headaches and excessive reduction of blood pressure with loss of consciousness. Elderly patients with impaired liver and kidney function and arterial hypotension require dose adjustment. At the time of treatment should be deleted reception of ethanol. If necessary, the appointment during lactation should abandon breastfeeding. During treatment (especially in the beginning) should refrain from vehicles and Occupation of driving potentially hazardous activities that require high concentration and psychomotor speed reactions.

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fluoxymesterone halotestin

The drug is administered intravenously slowly for at least 60 minutes, at 250-500 mg 1-2 times a day. Doses are determined by the nature and severity of the infection and the sensitivity of the alleged pathogen.

From the digestive fluoxymesterone halotestin system: nausea, vomiting, diarrhea (including blood), indigestion, loss of appetite, abdominal pain, colitis psevdomsmbranozny; increased activity of “liver” transaminases, hyperbilirubinemia, hepatitis, dysbiosis.

Cardio-vascular system: decrease in blood pressure, circulatory collapse, tachycardia, atrial fibrillation, prolongation of the interval .

From a metabolism: hypoglycaemia (increased appetite, increased sweating, trembling).

From the nervous system: headache, dizziness, weakness, sleepiness, insomnia, tremor, anxiety, paresthesia, anxiety, hallucinations, confusion, depression, movement disorders, convulsions, seizures (in predisposed patients).

From the senses: blurred vision, hearing, smell, taste and tactile sensitivity.

From the musculoskeletal system: arthralgia, muscle weakness, myalgia, tendon rupture, tendivit, rhabdomyolysis.

From the urinary system: giperkreatinemiya, interstitial nephritis, acute renal failure.

From the side of hematopoiesis: eosinophilia, hemolytic anemia, leukopenia, neutropenia, agranulocytosis, thrombocytopenia, pancytopenia, hemorrhage.

Allergic reactions: itching, and flushing of the skin, swelling of the skin and mucous membranes, urticaria, malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome), bronchospasm, asthma, anaphylactic shock, hypersensitivity pneumonitis, vasculitis.

Local reactions: pain, redness at the injection site, phlebitis.

Other: fatigue, aggravation fluoxymesterone halotestin of porphyria, persistent fever, the development of superinfection, photosensitization.

Overdosing Symptoms : nausea, erosive lesions of the mucous membranes of the gastrointestinal tract, the lengthening of the interval QT, confusion, dizziness, seizures. Treatment : symptomatic, dialysis is ineffective.

Interaction with other drugs
increases the half-life of cyclosporin.

Nonsteroidal anti-inflammatory drugs, theophylline, increase the risk of seizures, corticosteroids increase the risk of tendon rupture.

Cimetidine and drugs that block tubular secretion, slows down.

Levofloxacin compatible infusion solution with 0.9% sodium chloride, 5% dextrose, Ringer’s solution, 2.5% dextrose, combined solutions for parenteral nutrition (amino acids, carbohydrates, electrolytes).

You can not mix with heparin and solutions having an alkaline reaction.

Specific guidance
After normalization of body temperature, it is recommended to continue treatment for at least 48-72 hours.

The duration of an intravenous infusion of 500 mg (100 ml infusion solution) should be at least 60 minutes.

During treatment should avoid sunlight and artificial UV radiation in order to avoid damage to the skin (photosensitivity).

If signs of tendinitis, pseudomembranous colitis levofloxacin immediately overturned.

It should be borne in mind that in patients with brain damage history (stroke, major trauma) may develop seizures, with insufficient glucose-6-phosphate dehydrogenase – the risk of hemolysis.

In the period of treatment must be careful when driving vehicles and occupation of other potentially hazardous activities that require high concentration and psychomotor speed reactions.

In the course of therapy should be aware of the possibility of superinfection development.

With the combination fluoxymesterone halotestin of levofloxacin with vitamin K antagonists should be monitored for indicators of blood coagulation. Running low dose t3 clen cycle trying to lose bodyfat isn’t a real hot idea imo. bodybuilding frauen klassen Anabolika kaufen l arginin bodybuilding

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Ftorhnnolon, the antimicrobial is a broad spectrum bactericidal action. Blocks  gyrase (topoisomerase II) and topoisomerase IV, and crosslinking gives supercoiling  breaks, inhibits  synthesis, causes profound morphological change in the cytoplasm, the cell wall and membranes of microorganisms.

Levofloxacin is active against most strains of microorganisms in conditions in vitro and in vivo.

In vitro:
Sensitive organisms (minimum inhibitory concentrationhalotestin buy.

Aerobic gram-positive microorganisms: Corynebactcrium diphtheriae; Enterococcus spp, incl Enterococcus faecalis…; Listeria monocytogenes; Staphylococcus spp. (.. Incl coagulase metitsillinchuvstvitslnye / moderately susceptible), Staphylococcus aureus (metitsillinchuvstvitelnye), Staphylococcus cpidermidis (metitsillinchuvstvitelnye); Streptococci of groups C and G, Streptococcus agalacliae, Streptococcus pneumoniae (penitsillinchuvstvitelnye / moderately sensitive / resistant), Streptococcus pyogenes, Streptococci Group Viridans.

Anaerobic microorganisms; Bacteroidcs fragilis; Bifidobacterium spp, Clostridium perfringens.; Fusobacterium spp .; Peptostreptococcus spp .; Propionibactcrum spp .; Veilonella spp.

Other micro-organisms: Bartonella spp .; Chlamydia pneumoniae, Chlamydia psillaci, Chlamydia trachomatis; … Legionella spp, incl Legionella pneumophila;Mycobacterium spp .. incl Mycobacterium leprae, Mycobacterium tuberculosis..; Mycoplasma hominis, Mycoplasma pneumoniae; Rickettsia spp., Ureaplasma urealylicum.

Levofloksatsin moderately active (MIC ≥4 mg / l):
Aerobic Gram-positive microorganisms: Corynebacterium urcalilicum, Corynebacterium xerosis; Entcrococcus faecium; Staphylococcus epidermidis (methicillin-resistant); Staphylococcus haemolyticus (methicillin-resistant).

Aerobic gram-negative halotestin buy microorganisms: Burkbolderia cepacia; Campilobacter jejuni. Campilobacter coli.

Anaerobic microorganisms: Bacteroides thelaiotaomicron, Bacteroides vulgatus, Bacteroides ovatus; Prevolella spp .; Porphyromonas spp.

By levofoloksatsinu resistant (MP K ≥ 8 mg / L):
Aerobic gram-positive mikpoopganizmy: Corynebacterium jeikeium; Staphylococcus aureus (methicillin-resistant), Staphylococcus spp. . koagulazonsgativnye (methicillin-resistant)
Aerobic gram-negative microorganisms:. Alcaligenes xylosoxidans
Other micro-organisms: Mycobacterium avium.

With intravenous administration of single and multiple apparent volume of distribution after administration of the same dose of 89-112 l.

Relationship to plasma proteins – 30-40%. Well into the organs and tissues – lungs, bronchial mucosa, sputum, organs of the urogenital system, bone tissue, cerebrospinal fluid, the prostate gland, polymorphonuclear leukocytes, alveolar macrophages.

Metabolism and excretion: In the liver, a small part of the oxidized and / or deacetylated. Report from the body mainly by the kidneys by glomerular filtration and tubular secretion. The half-life – 6.4 hours.

In renal insufficiency, reduced clearance of the drug and its excretion by the kidneys is dependent on the degree of decline in creatinine clearance.

Indications
Infectious-inflammatory halotestin buy diseases, caused by susceptible microorganisms:
– lower respiratory tract (exacerbation of chronic bronchitis, community-acquired pneumonia);
– LOP-organs (including acute sinusitis);
– by mochevyyvodyaschih and kidney (including acute pyelonephritis);
– bacterial chronic prostatitis;
– skin and soft tissue infections (atheroma festering abscess, furunculosis);
– septicemia / bacteremia;
– intra-abdominal infections;
– in the complex therapy of drug-resistant forms of tuberculosis.

Contraindications
– giperchuvstvitslnost (including to other quinolones);
– epilepsy;
– the defeat tendons at the earlier treatment of quinolones;
– childhood and adolescence (growth period) 18;
– Pregnancy
– Lactation;

With care : the elderly (due to the high probability of the presence of a concomitant decrease in renal function), with a deficit of glucose-6-fosfatdsgidrogenazy. anabolic steroids online shop

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halotestin tablets

Do dampening effect on the central nervous system of ethanol, sedative and antipsychotic drugs (neuroleptics), antidepressants, narcotic analgesics, drugs for general anesthesia, muscle relaxants.
Inhibitors halotestin tablets of microsomal liver enzymes (including cimetidine, oral contraceptives, erythromycin, disulfiram, fluoxetine, isoniazid, ketoconazole, metoprolol, propranolol, propoxyphene, valproic acid) extend the T 1/2 and enhance the effect.
Inductors of microsomal liver enzymes (rifampicin, carbamazepine, caffeine) reduce efficiency.
Narcotic analgesics increase the euphoria, leading to an increase in psychological dependence.
Antacids drugs reduce the rate of absorption of diazepam from the gastrointestinal tract, but not its fullness.
Antihypertensive drugs may increase the severity of blood pressure reduction.
On the background of the simultaneous use of clozapine may increase the respiratory depression.
while the use of low polarity cardiac glycosides (digitoxin) may increase the concentration . the latter in blood serum and the development of glycoside intoxication (as a result of competition for the connection with halotestin tablets plasma proteins)
reduces the effectiveness of levodopa in patients with Parkinson’s disease.
omeprazole prolongs the elimination of diazepam.
monoamine oxidase inhibitors, analeptics, psychostimulants – reduce activity.
Premedication with diazepam reduces the dose of fentanyl required for introduction of general anesthesia and to reduce the time required to “off” consciousness via induction doses.
it may increase the toxicity of zidovudine.
Rifampin may increase excretion of diazepam and lowering its concentration in plasma.
Theophylline (used in low doses) may reduce or distort sedative act.

special instructions

The risk of formation of drug dependence increases at high doses (60 mg / day), a significant duration of treatment, patients previously abusing alcohol or drugs. Without specific instructions, should not be used for a long time.
Not recommended for monotherapy of benzodiazepines with a combination of anxiety with depression (suicide attempts are possible). If you have any patients paradoxical reactions such as increased aggression, acute state of excitement, anxiety, anxiety, suicidal thoughts, hallucinations, increased muscle cramps, difficult to fall asleep, sleep surface, diazepam should be discontinued. Be wary appoint patients with personality and behavioral disorders. Paradoxical reactions are more common in children and elderly patients.
Acute glaucoma attack is a contraindication to the appointment of diazepam.
Diazepam can cause amnesia. The duration of amnesia depends on the dosage.
In the treatment of patients is strictly prohibited the use of ethanol. Smoking weakens the effect of the drug.
In renal / hepatic failure and prolonged treatment is necessary to monitor patterns of peripheral blood and the activity of “liver” enzymes.
It is not permissible abrupt discontinuation of treatment because of the risk of the syndrome of “cancellation” (convulsions, tremor, abdominal cramps and muscle pain, vomiting, sweating), but thanks to slow thehalotestin tablets diazepam expressed its manifestation is much weaker than that of other benzodiazepines.
Initiation of treatment with diazepam or abrupt withdrawal in patients with epilepsy or with a history of seizures may accelerate the development of seizures or status epilepticus.
When using large doses of diazepam developed mild hypotension. Patients with profound disorders of cardiac activity can develop significant hypotension, especially against the background of severe hypovolemia.
Children, especially at a younger age, are very sensitive to depress the central nervous system action of benzodiazepines.
In the period of treatment must be careful when driving vehicles and occupation of other potentially hazardous activities that require high concentration and speed of psychomotor reactions.

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